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Updates --> * A new visualisation tool to see the association among ILDs, DCGs and miRNAs/ SNPs. * Updated and verified ILD classes and DCGs incorporated. * Search and presentation of References has been improved and the association is shown as a network view.

ILDgenDB (Interstitial Lung Disease Genetic Database)

ILDgenDB is an integrated resource to facilitate genetic based ILD diagnosis and prognosis. This resource is a repertoire of ILDs related genetic data, and contains 299 literature curetted disease candidate genes (DCGs) and their association with SNPs, miRNA, biomarkers, pathways, biological processes, etc. The DCGs involvement in ILDs was verified by mining disease related data from databases such as GAD, OMIM, GHR, CTD, DISEASE and GeneCards. Annotations and characterization of all DCGs were carried out through gene ontology (GO), phenotype and pathways mapping analyses. Associations of DCGs with regulatory elements such as miRNAs and SNPs were also provided. Biomarkers used for ILDs diagnostics were manually curetted and were incorporated into the database. SNP-Gene (DCGs), miRNA-DCGs, miRNA-SNP and SNP-miRNA-DCG interaction analyses were incorporated into the resource after manual verifications of their relevance. All these data were interlinked and integrated into the web resource, and user may access data using ten different diverse ‘key words” as queries. Tutorial

Architecture, diverse query terms and data with work flow of ILDgenDB resource is given in Figure I


Figure I: Architecture of ILDgenDB knowledge resource.

This comprehensive web resource provides genetic and other data primarily for 24 major interstitial lung diseases :

Idiopathic Interstitial Pneumonia (IIP)

Acute Interstitial Pneumonia (AIP)

Bronchiolitis or Cryptogenic Organizing Pneumonia (COP)

Desquamative interstitial pneumonia (DIP)

Idiopathic pulmonary fibrosis (IPF)

Lymphocytic interstitial pneumonia (LIP)

Nonspecific interstitial pneumonia (NSIP)

Respiratory bronchiolitis interstitial lung disease (RB-ILD)

Unclassified Idiopathic Interstitial Pneumonia (IIP)

Systemic Disease–Associated Interstitial Lung Disease

Collagen vascular disease associated interstitial lung diseases (CVD-ILDs)

Mixed connective tissue disease - ILDs (MCTD-ILDs)

Pulmonary Sarcoidosis (PS)

Rheumatoid arthritis-ILD (RA-ILD)

Scleroderma-associated ILDs (SSc-ILDs)

Systemic lupus erythematosus (SLE)

Systemic sclerosis (SSc)

Tuberous Sclerosis

Exposure-Related and Congenital Interstitial Lung Disease

Hypersensitivity pneumonitis (HP)

Pulmonary alveolar proteinosis (PAP)

Pulmonary Surfactant dysfunction (pSD)

Silicosis

Unclassified/Other Interstitial Lung Diseases (ILDs)

Children's Interstitial Lung Disease (ChILD)

Lymphangioleiomyomatosis (LAM)

Pulmonary Langerhans Cell Histiocytosis (pLCH)

Unclassified Interstitial lung disease (ILDs))



Salient features of ILDgenDB resource

  • An integrated high quality knowledge resource for ILD diseases candidate genes (DCGs), and their functional annotation and     interactions with regulatory elements.
  • DCGs involvements in various biological processes are provided and analyzed to decipher mechanism of disease.
  • Candidate potential biomarkers of ILDs and their cross referencing results of ILD genomics experiments are also provided.
  • Potential significant SNP-Gene (DCGs), miRNA-DCGs, miRNA-SNP and SNP-miRNA-DCG interactions are provided to facilitate better therapeutics.
  • To provide systematic information retrieval for diverse users, this resource facilitates a query system with 10 different key words. This resource also provides “Browse” facility to access all genetic data through disease name.



  • Query System

    This resource provides interactive query retrieval system to assist the user to extract reliable as well as comprehensive information with ease. This data can be saved or retrieved in “selected” or “batch” mode.